CREB Binding Protein Role in cell cycle regulation
Acetylation of histones, specifically lysine residues in the histones, weakens the electric charge interaction (FREQUENCY) between the histone and DNA, causing this area to become more open and accessible for the machinery required for DNA replication.
FREQUENCY determines physiology!
Deregulation on CREBBP allows the buildup of a substance called oxalates (Hyperoxaluria), impairment of intellectual development, and facial dysmorphisms. Feeding difficulties, autistic behavior, recurrent upper airway infections, hearing impairment, short stature, and microcephaly are also frequently seen.
CREBBP (CREB binding protein) regulates the activity of many genes in tissues throughout the body. It plays an essential role in controlling cell growth and division.
Studies show that this protein is involved in the development of the brain and may also be involved in the formation of long-term memories.
CREB binding protein carries out its functions by turning on (activating) transcription, which is the first step in the production of proteins from the instructions stored in DNA.
CREB knockout mice exhibit embryonal and neuronal deficits and have a reduced lifespan.
Overexpression of CREB is associated with aberrant signal transduction caused by the deregulated expression of downstream genes that control the hallmarks of cancer, such as proliferation, apoptosis, angiogenesis, metastasis, immune surveillance, and metabolism, and the generation of tumor stem cells, which lead to the initiation and progression of tumors.
Mechanism of action
A typical (albeit somewhat simplified) sequence of events is as follows: A signal arrives at the cell surface, activates the corresponding receptor, which leads to the production of a second messenger such as cAMP or Ca2+, which in turn activates a protein kinase. This protein kinase translocates to the cell nucleus, where it activates a CREB protein. The activated CREB protein then binds to a CRE region, and is then bound to by CBP (CREB-binding protein), which coactivates it, allowing it to switch certain genes on or off.